Author Correction: Structural basis of temperature sensation by the TRP channel TRPV3
نویسندگان
چکیده
منابع مشابه
Trp ion channels and temperature sensation.
The abilities to sense environmental and internal temperatures are required for survival, both for maintenance of homeostasis and for avoidance of tissue-damaging noxious temperatures. Vertebrates can sense external physical stimuli via specialized classes of neurons in the peripheral nervous system that project to the skin. Temperature-sensitive neurons can be divided into two classes: innocuo...
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In the skin, cannabinoid lipids, whether of endogenous or exogenous origin, are capable of regulating numerous sensory, homeostatic, and inflammatory events. Although many of these effects are mediated by metabotropic cannabinoid receptors, a growing body of evidence has revealed that multiple members of the transient receptor potential (TRP) ion channel family can act as "ionotropic cannabinoi...
متن کاملThe emerging role of TRP channels in mechanisms of temperature and pain sensation.
Pain is universal and vital to survival. It is an essential component of our sense of touch; together, touch and pain have evolved to enable our awareness of the intricacies of our environment and to warn us of danger and possible injury. There is a clear link between temperature sensation and pain-painful temperature sensations occur acutely and are a hallmark of inflammatory and chronic pain ...
متن کاملOxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.
Factor inhibiting HIF (FIH, also known as HIF1AN) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing ankyrin repeat domains (ARDs) have been characterised as substrates of FIH, although there is little evidence for a functional consequence of hydroxylation on these substrates. This study demonstrates that the transient...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2020
ISSN: 1545-9993,1545-9985
DOI: 10.1038/s41594-020-0376-x